A comic road-movie, set on a train in India, following three brothers on a road-to-nowhere as they try to bond with one another after the death of their father. Trying to rekindle their sibling affections, Francis (Owen Wilson), Peter (Adrien Brody), and Jack (Jason Schwartzman) Whitman travel across India to meet up with their mother (Anjelica Huston), who has forsaken western life to become a nun in the Himalayas. Along the way, the hapless brothers fall victim to a range of mishaps, as their well-intentioned trip spirals out of control.